REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
p-ERK	Cell Signaling Technology	Cat# 9101
p-AKT (S473)	Cell Signaling Technology	Cat# 9271
PD-L1 (anti-human)	eBioscience	Cat# 12-5983-42
Isotype control	eBioscience	Cat# 9012-4714-025
PD-L1 (anti-mouse)	eBioscience	Cat# 14-5982-82
Isotype control	eBioscience	Cat# 12-4321-41
CD31	eBioscience	Cat# 11-0311-81
TTP	Santa Cruz	Cat# sc-8458
TTP endogenous	Merck Millipore	Cat# ABE285
KSRP	Cambridge Bioscience	Cat# A302-021A
KSRP	Cell Signaling Technology	Cat# 5398S
Myc (9E10)	Francis Crick Institute Cell Services	N/A
ERK	Cell Signaling Technology	Cat# 9107
AKT	Cell Signaling Technology	Cat# 2920
p-PXSP	Cell Signaling Technology	Cat# 2325
p-RXXS/T	Cell Signaling Technology	Cat# 9611
p-p38 (T180/Y182)	Cell Signaling Technology	Cat# 9211
CD3	Abcam	Cat# ab134096
IFN-γ XMG1.2	eBioscience	Cat# 12-7311-41
Foxp3 FJK16s	eBioscience	Cat# 72-5775-40
CD45 30-F11	BioLegend	Cat# 103129
CD4 GK1.5	Francis Crick Institute Cell Services	N/A
CD4 GK1.5	eBioscience	Cat# 25-0041-81
CD4 RM4-5	eBioscience	Cat# 11-0042-81
CD8 53-6.7	BD Biosciences	Cat# 563786
CD8 2.43	Francis Crick Institute Cell Services	N/A
CD3 17A2	BioLegend	Cat# 100204
CD45	eBioscience	Cat# 11-0451-82
IFN-γ NIB42	eBioscience	Cat# 14-7318-81
Bacterial and Virus Strains
Adenovirus for expression of Cre recombinase	Gene Transfer Vector Core. University of Iowa.	N/A
XL10-Gold Ultracompetent Cells	Agilent Technologies	Cat# 200314
Chemicals, Peptides, and Recombinant Proteins
Lipofectamine 2000	ThermoFisher	Cat# 11668027
DharmaFECT 1	Dharmacon	Cat# T-2001-01
Trametinib	Selleckchem	Cat# S2673
ARS853	A gift from the Shokat Laboratory	N/A
GDC-0941	Selleckchem	Cat# S1065
4-OHT	Sigma-Aldrich	Cat# H7904
PMA	Sigma-Aldrich	Cat# P1585
Actinomycin D	Sigma-Aldrich	Cat# A1410
N-Acetyl-L-cysteine	Sigma-Aldrich	Cat# A9165
Glutathione reduced ethyl ester	Sigma-Aldrich	Cat# G1404
PF-3644022 hydrate	Sigma-Aldrich	Cat# PZ0188
MK2 inhibitor III	Merck Millipore	Cat# 475864
Doxycycline hyclate	Sigma-Aldrich	Cat# D9891
Ionomycin	Sigma-Aldrich	Cat# I0634
GolgiPlug	BD Bioscience	Cat# BDB555029
Human Interferon gamma	Biolegend	Cat# 570206
Ruxolitinib	Selleckchem	Cat# S1378
DAPI	ThermoFisher	Cat# D1306
Fixable viability dye eFluor 780	eBioscience	Cat# 65-0865-14
H2DCFDA	ThermoFisher	Cat# C6827
Critical Commercial Assays
Dual-Luciferase Reporter Assay	Promega	Cat# E1910
Magna-RIP Kit	Merck Millipore	Cat# 17-700
Anti-Mouse/Rat Foxp3 Staining Set PE	eBioscience	Cat# 72-5775-40
QuikChange II XL Site-Directed Mutagenesis Kit	Agilent Technologies	Cat# 200521
RNeasy Mini Kit	QIAGEN	Cat# 74104
Dynabeads Protein G for Immunoprecipitation	ThermoFisher	Cat# 10003D
SYBR Green Fast Master Mix	ThermoFisher	Cat# A25742
Experimental Models: Cell Lines
H358	ATCC	N/A
A427	Francis Crick Institute Cell Services	N/A
H1792	ATCC	N/A
KPB6	Sergio Quezada Laboratory	N/A
Type II pneumocytes	Olivier Pardo, Michael Seckl (Imperial College, London) and (Molina-Arcas et al., 2013)	N/A
SW837	Francis Crick Institute Cell Services	N/A
H23	Francis Crick Institute Cell Services	N/A
293FT	Francis Crick Institute Cell Services	N/A
TTP KO and TTP WT MEFs	Perry Blackshear Laboratory	N/A
MCF10A	Molina-Arcas et al., 2013	N/A
CT26	Francis Crick Institute Cell Services	N/A
A549	Francis Crick Institute Cell Services	N/A
MC38	George Kassiotis Laboratory	N/A
Experimental Models: Organisms/Strains
C57BL/6	The Francis Crick Institute Biological Resources Unit; Originally The Jackson Laboratory	Stock Number #000664
BALB/c	The Francis Crick Institute Biological Resources Unit; Originally The Jackson Laboratory	Stock Number #001026
KrasLSL-G12D/+/Trp53Flox/Flox (B6.129-Krastm4Tyj/Nci and FVB.129P2-Trp53tm1Brn/Nci)	The Francis Crick Institute Biological Resources Unit; Originally Mouse Models of Human Cancer Consortium	Strain Number# 01XJ6; 01XC2
Nu/nu (Foxn1nu)	The Francis Crick Institute Biological Resources Unit; Originally ICRF Stock	N/A
Oligonucleotides
siGENOME x4 TTP	Dharmacon	Cat# MU-010789-02-0002
siGENOME x4 AUF1	Dharmacon	Cat# MU-004079-01-0002
siGENOME x4 KSRP	Dharmacon	Cat# MU-009490-01-0002
siGENOME x4 HuR	Dharmacon	Cat# MU-003773-04-0002
siGENOME x4 BRF1	Dharmacon	Cat# MU-011816-00-0002
siGENOME x4 BRF2	Dharmacon	Cat# MU-013605-02-0002
siScramble Control	Dharmacon	Cat# D-001810-10-05
Recombinant DNA
peGFPC1-6XHis-FL-KSRP	A gift from Douglas Black	Addgene plasmid # 23001
PD-L1 + wild type 3′UTR mouse ORF clone NM_021893.3	Creative Biogene	N/A
pUNO-mcs	InvivoGen	Cat# puno1-mcs
pTRIPZ	Dharmacon	Cat# RHS4740
pcDNA3.1	ThermoFisher	Cat# V79020
pGL3 Control	Promega	Cat# E1741
pGL3 Basic	Promega	Cat# E1751
pRL-TK Control	Promega	Cat# E2241
Software and Algorithms
FlowJo	Tree Star	N/A
Prism 7	GraphPad	N/A
Skyline v.3.5.0.9319	McCoss Lab Software	N/A