Table 4.
Stereological estimates in postmortem schizophrenia studies of the pulvinar.
| Authors (year) | Brain banka | Region(s) | Schiz/Cont/Otherb | Mean age (years) | Estimatesc | Reported significant schiz. related diff.d |
|---|---|---|---|---|---|---|
| Byne et al. (2002) | 1 | Right pulvinar | 4M6F/4M1Fe | 66.6/75.0 | V | Decreased V21% |
| Danos et al. (2003) | 3 | Right and left medial pulvinar | 7M5F/7M2F2?f | 50.7/51.6g | V | Decreased V 20% left, 22% right |
| Highley et al. (2003) | 2 | Right and left medial (MP) and lateral (LP) pulvinar | 12M7F4?/12M10F3?h | 62–73/67–73i | V, N(neu) | Right side only: Decreased V: MP 14%, LP 26% & N: LP 24% |
| Byne et al. (2007) | 1 | Right pulvinar (P) incl. medial (M) and inferior/lateral (IL) parts | 8M5F/7M3F | 66.6/72.5 | V | Decreased V: P 19%, M 24% |
| Young et al. (2007) | 8 | Right orj left pulvinar | 6M3F3?/9M6F/5M2F4?/5M2F4?j | 44.2/48.1/46.4/42.3k | V, N(neu) | No differences |
| Mileaf & Byne (2012) | 8 | Right orl left medial pulvinar | 7M2F/7M5F | 44/46 | N(neu, oligo) | Right side only: Decreased N(neu)?%m |
Positive findings in bold.
Brain bank according to Table 1.
Number of males (M) and females (F) in each diagnostic group: Schizophrenia (Schiz), Control (Cont) group, Other diagnostic group(s).
Abbreviations: V volume; N number; neu neuron; oligo oligodendrocyte.
Statistically significant differences for the schizophrenia group. Abbreviations as in “Region(s)” and “Estimates” columns.
“Restricted” subject groups without Alzheimer’s type pathology. The results listed are for these subjects without Alzheimer’s type pathology. Full subject sample: 14 Schiz, 8 Cont.
Two Cont excluded without details from the full study sample of 12 Schiz and 13 Cont. Thus, sex not reported for two subjects.
Mean ages for the full study sample of 12 Schiz and 13 Cont.
Base sample of 16M11F Schiz and 15M13F Cont reported with summary statistic in paper. Used sample: 21-23 Schiz and 21-25 Cont per side, per estimate, without further details. I.e. exact number, sex and age of subjects for each estimate not reported in the paper. Inferred numbers of males and females for max sample of 23 Schiz and 25 Cont listed here.
Mean ages for base sample of 27 Schiz and 28 Cont.
Schiz 3R6L3?; Cont 7R8L; Major Depression (MDD) 2R5L4?; Bipolar Disorder (BPD) 4R3L4?. Three Schiz, four MDD, and four BPD excluded without details from the base sample of 15 Schiz, 15 Cont, 15 MDD, and 15 BPD. Thus, side and sex not reported for 11 subjects. R right, L left.
Mean ages for base sample of 15 Schiz, 15 Cont, 15 MDD, and 15 BPD.
Schiz 6R3L; Cont 7R5L.
Right and left combined: N(neu) 14% decrease but not statistically significant. N(neu) for right side significant smaller but difference not reported.