Fig 9. ROC curves comparing the predictive performance of different combinations of sequence-based diversity measures of HIV-1 gp120 conserved subdomains to identify HIV-1 infection recency.

Five combinations of sequence-based diversity measures were analyzed. Shannon entropy + percent diversity + percent complexity: P1; percent diversity+ number of haplotypes+ percent complexity: P2; number of haplotypes+ percent complexity: P3; Shannon entropy+ percent complexity: P4 and percent diversity+ percent complexity: P5. Seven HIV-1 env segments were considered: gp120-C2_1; gp120-C2_2; gp120-C2_3; gp120-C3_1; gp120-C3_2; gp120-C4 and gp120-C5. ROC = receiver operating characteristics; AUC = area under the curve. AUC values between 0.8 and 1 were considered performance measures.