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. 2017 Dec 28;12(12):e0189623. doi: 10.1371/journal.pone.0189623

Table 1. Model inputs and data sources.

Model input Data Source Year(s) Value(s)
Kenya population estimates Kenya Population and Housing Census 2009 http://www.knbs.or.ke/index.php?option=com_phocadownload&view=category&download=584:volume-1c-population-distribution-by-age-sex-and-administrative-units&id=109:population-and-housing-census-2009&Itemid=599 2009
• Women aged 15–49 years 9,375,784
• Infants 0–11 months 1,221,937
Population growth rate (average annual %) UN Data http://data.un.org/CountryProfile.aspx?crName=kenya 2010–2015 2.7
General fertility rate per 1000 women aged 15–44 years Kenya Demographic and Health Survey 2008–2009 http://www.dhsprogram.com/pubs/pdf/FR229/FR229.pdf 2006–2008 161
Infant mortality rate per 1000 live births Kenya Demographic and Health Survey 2008–2009 2004–2008 52
Mortality rate among respiratory admissions (%) KEMRI Health and Demographic Surveillance 2010–2014
• Women aged 15–49 years 6.8 (95% CI 1.1–12.5)
• Infants aged 0–5 months 2.4 (95% CI 0.2–4.6)
Proportion of respiratory deaths occurring outside of the hospital (%) KEMRI Health and Demographic Surveillance
• Women aged 15–49 years 2010 66.7 (95% CI 29.9–92.5)
2011 55.6 (95% CI 21.2–86.3)
2012 46.2 (95% CI 19.2–74.9)
• Infants aged 0–5 months 2010 91.2 (95% CI 88.0–97.0)
2011 83.7 (95% CI 72.7–88.5)
2012 73.5 (95% CI 67.8–85.9)
Annual influenza-associated hospitalization rate/100,000 KEMRI Population Based Infectious Disease Surveillance 2010–2014
• Women aged 15–49 years 39.9 (95%CI 25.3–62.9)
• Infants aged 0–5 months 129.4 (95% CI 45.8–365.7)
Increased odds of influenza-associated hospitalization in pregnancy from 3 sites KEMRI, Malawi-Liverpool-Wellcome Trust, and National Institute for Communicable Diseases, South Africa [30] 2009–2015 2.9 (95% CI 1.0–12.25)
Estimated number of cases per hospitalization KEMRI Population Based Infectious Disease Surveillance 2010–2014
• Women aged 15–49 years 23
• Infants aged 0–5 months 16
Proportion of illnesses that are medically attended (%) KEMRI Population Based Infectious Disease Surveillance 2010–2014
• Women aged 15–49 years 13
• Infants aged 0–5 months 42
Proportion of pregnant women with 2 or more antenatal care visits (%) Kenya Demographic and Health Survey 2008–2009 2008–2009 86
Vaccine effectiveness (%) Estimated using 1-risk ratio (RR); RR estimated using random effects Mantel-Haenszel model of published randomized controlled trials of inactivated influenza vaccine in pregnant women (see text for references)
• Women aged 15–49 years 2011–2014 61.0% (95% CI, 43.2–73.2%) n = 6430
• Infants aged 0–5 months 2008–2014 56.4% (95% CI 38.6–69.0) n = 6658
Vaccine coverage with 2 doses of tetanus toxoid among pregnant women (%) Kenya Demographic and Health Survey 2008–2009 2008 55