Table 1. Experimentally validated LC8 binding motifs in the Hippo pathway.
| Gene name | UniProt Accession | Start | Binding motif sequence | Kd(μM)±SD |
|---|---|---|---|---|
| WWC1* | Q8IX03 | 278 | LDVSSQTD | 0.45±0.03 |
| WWC1* | Q8IX03 | 887 | VDKETNTE | 4.00±0.50 |
| WWC2 | Q6AWC2 | 282 | LDAGSQTS | 32.7±2.97 |
| WWC2 | Q6AWC2 | 962 | VDKETNTD | 17.6±0.54 |
| WWC3 | Q9ULE0 | 208 | CDAGSQTD | 5.34±0.18 |
| WWC3 | Q9ULE0 | 867 | VDKETNTE | 3.50±0.15 |
| AMOT | Q4VCS5 | 860 | RDCSTQTE | 1.20±0.04 |
| AMOTL1 | Q8IY63 | 873 | KDSSTQTD | 1.55±0.04 |
| AMOTL2 | Q9Y2J4 | 724 | RDGSTQTE | 1.98±0.19 |
*The two WWC1 motifs were validated in a previous study [49]