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. 2017 Dec 28;13(12):e1006753. doi: 10.1371/journal.ppat.1006753

Fig 6. C46CD4CAR cells protect CD4+ T-cells and decrease viral load in multiple tissues.

Fig 6

(A-C) GI biopsies were collected from colon and duodenum/jejunum from C46CD4CAR and control animals prior to SHIV infection, and after infection and cART withdrawal. Shown are CD4/8 ratio (A), %CD4+ T cells (B) and %CD4+ effector memory T-cells (C). D) At necropsy, Taqman was used to measure lentivirus gene marking from lymphoid tissues (spleen and mesenteric, axillary, inguinal, and submandibular lymph nodes), gastrointestinal tract (duodenum, jejunum, ileum, cecum, colon, rectum) and brain tissues (hippocampus, basal ganglia, thalamus, parietal cortex, cerebellum). E) Normalized SHIV RNA copy number from same tissues as in (D). * p<0.01, **p<0.001, ***p<0.0001 by Mann-Whitney test.