Table 1. Inhibition of acetylcholinesterase (AChE) activity in adult S. mansoni and S. haematobium Triton X-100-soluble extracts and S. mansoni soluble egg extract (SEA) by a series of ruthenium complexes.
| ta | S. mansoni extract | S. haematobium extract | S. mansoni SEA | |||
|---|---|---|---|---|---|---|
| AChE Inhibition (%)a, b | IC50 (μM)b | AChE Inhibition (%)a, b | IC50 (μM)b | AChE Inhibition (%)a, b | IC50 (μM)b | |
| Ru(phen)2(Me2bpy) | 9.3 ± 1.8 | 67.0 ± 11.6 | 13.3 ± 1.8 | 90.2 ± 1.2 | 66.5 ± 5.8 | ND |
| Rubb12-mono | 11.1 ± 0.8 | 18.9 ± 2.8 | 52.2 ± 0.5 | 1.1 ± 0.1 | 73.5 ± 4.9 | ND |
| Rubb12-di | 73.9 ± 0.5 | 1.6 ± 0.3 | 20.9 ± 0.2 | 16.8 ± 0.4 | 94.2 ± 0.8 | ND |
| Rubb7-tri | 84.3 ± 4.5 | 0.4 ± 0.0 | 37.2 ± 0.3 | 0.4 ± 0.0 | 77.5 ± 0.6 | ND |
| Rubb10-tri | 78.7 ± 0.7 | 0.5 ± 0.0 | 73.6 ± 2.0 | 3.0 ± 0.0 | 91.3 ± 0.3 | ND |
| Rubb12-tri | 89.4 ± 0.4 | 0.3 ± 0.0 | 87.6 ± 0.4 | 0.7 ± 0.0 | 96.3 ± 1.4 | 0.2 ± 0.0 |
| Rubb16-tri | 46.8 ± 1.1 | 1.9 ± 0.0 | 31.6 ± 0.5 | 18.0 ± 0.1 | 89.7 ± 0.1 | ND |
| Rubb7-tl | 73.4 ± 1.5 | 1.0 ± 0.0 | 24.8 ± 0.3 | 36.4 ± 4.4 | 78.7 ± 8.0 | ND |
| Rubb12-tl | 89.9 ± 1.6 | 0.3 ± 0.0 | 55.4 ± 2.6 | 1.0 ± 0.1 | 97.2 ± 0.6 | 0.2 ± 0.0 |
| Rubb16-tl | 76.3 ± 1.6 | 2.4 ± 0.1 | 59.3 ± 0.1 | 1.9 ± 0.1 | 90.8 ± 0.2 | ND |
| Rubb7-tnl | 84.0 ± 0.6 | 0.9 ± 0.1 | 19.5 ± 0.3 | ND | 98.1 ± 0.3 | ND |
| Rubb12-tnl | 80.0 ± 0.1 | 0.4 ± 0.0 | 75.9 ± 2.5 | 3.2 ± 0.0 | 92.7 ± 0.3 | 0.3 ± 0.0 |
| Rubb16-tnl | 73.0 ± 0.8 | 2.3 ± 0.1 | 51.1 ± 6.0 | ND | 89.6 ± 0.1 | ND |
ainhibition of Sm-AChE activity assessed at 1μM.
bdata represents the mean of duplicate experiments ± SE