Table 1. Gene ontology (GO) categories (biological process, BP and metabolic function, MF) enriched across the T. cruzi CL Brener and CL-14 life cycles.
| GO Term (CL Brener) | P value | Num. DE | Total Num. | |
|---|---|---|---|---|
| Trypomastigote to Amastigote 60 hpi, up-regulated | ||||
| GO:0006412 | translation (BP) | 2.52E-55 | 177 | 475 |
| GO:0016491 | oxidoreductase activity (MF) | 6.13E-17 | 109 | 455 |
| GO:0006811 | ion transport (BP) | 3.57E-16 | 56 | 165 |
| GO:0006457 | protein folding (BP) | 1.87E-15 | 45 | 118 |
| GO:0051276 | chromosome organization (BP) | 2.47E-12 | 30 | 70 |
| GO:0008610 | lipid biosynthetic process (BP) | 5.87E-10 | 40 | 134 |
| Trypomastigote to Amastigote 60 hpi, down-regulated | ||||
| GO:0004672 | protein kinase activity (MF) | 2.78E-04 | 32 | 418 |
| GO:0008645 | hexose transport (BP) | 4.02E-02 | 1 | 1 |
| Amastigote 60 hpi to Amastigote 96 hpi, up-regulated | ||||
| GO:0006565 | L-serine catabolic process (BP) | 3.51E-05 | 3 | 3 |
| GO:0001539 | cilium or flagellum-dependent cell motility (BP) | 7.82E-03 | 3 | 12 |
| Amastigote 60 hpi to Amastigote 96 hpi, down-regulated | ||||
| GO:0006457 | protein folding (BP) | 1.01E-05 | 8 | 118 |
| GO:0006730 | one-carbon metabolic process (BP) | 2.30E-04 | 2 | 3 |
| GO:0006811 | ion transport (BP) | 1.56E-02 | 5 | 165 |
| GO:0016491 | oxidoreductase activity (MF) | 2.00E-02 | 9 | 455 |
| Amastigote 96 hpi to Trypomastigote, up-regulated | ||||
| GO:0004672 | protein kinase activity (MF) | 2.13E-04 | 18 | 418 |
| GO:0008645 | hexose transport (BP) | 1.67E-02 | 1 | 1 |
| Amastigote 96 hpi to Trypomastigote, down-regulated | ||||
| GO:0016491 | oxidoreductase activity (MF) | 1.80E-15 | 69 | 455 |
| GO:0006457 | protein folding (BP) | 1.97E-12 | 29 | 118 |
| GO:0006757 | ATP generation from ADP (BP) | 1.41E-10 | 14 | 31 |
| GO:0008610 | lipid biosynthetic process (BP) | 3.25E-10 | 28 | 134 |
| GO:0006811 | ion transport (BP) | 2.71E-09 | 30 | 165 |
| GO:0051276 | chromosome organization (BP) | 1.56E-08 | 18 | 70 |
| GO:0009116 | nucleoside metabolic process (BP) | 9.22E-05 | 18 | 124 |
| GO:0006412 | translation (BP) | 1.49E-03 | 41 | 475 |
| GO Term (CL-14) | P value | Num. DE | Total Num. | |
| Trypomastigote to Amastigote 60 hpi, up-regulated | ||||
| GO:0006412 | translation (BP) | 1.39E-73 | 166 | 475 |
| GO:0051276 | chromosome organization (BP) | 3.56E-13 | 26 | 70 |
| GO:0006811 | ion transport (BP) | 5.08E-07 | 31 | 165 |
| GO:0006457 | protein folding (BP) | 5.11E-07 | 25 | 118 |
| GO:0016491 | oxidoreductase activity (MF) | 9.90E-06 | 58 | 455 |
| GO:0008610 | lipid biosynthetic process (BP) | 2.99E-03 | 19 | 134 |
| Trypomastigote to Amastigote 60 hpi, down-regulated | ||||
| GO:0004672 | protein kinase activity (MF) | 7.48E-04 | 29 | 418 |
| GO:0008645 | hexose transport (BP) | 3.68E-02 | 1 | 1 |
| Amastigote 60hpi to Amastigote 96 hpi, up-regulated | ||||
| GO:0051276 | chromosome organization (BP) | 2.79E-04 | 10 | 70 |
| GO:0006811 | ion transport (BP) | 7.65E-03 | 14 | 165 |
| Amastigote 60hpi to Amastigote 96 hpi, down-regulated | ||||
| GO:0016491 | oxidoreductase activity (MF) | 1.40E-02 | 24 | 455 |
| Amastigote 96 hpi to Trypomastigote, up-regulated | ||||
| GO:0004672 | protein kinase activity (MF) | 1.40E-02 | 30 | 418 |
| GO:0008645 | hexose transport (BP) | 4.86E-02 | 1 | 1 |
| Amastigote 96 hpi to Trypomastigote, down-regulated | ||||
| GO:0006412 | translation | 1.73E-47 | 151 | 475 |
| GO:0051276 | chromosome organization | 8.50E-15 | 31 | 70 |
| GO:0006811 | ion transport | 1.05E-11 | 46 | 165 |
| GO:0006720 | isoprenoid metabolic process | 3.47E-06 | 11 | 23 |
| GO:0016491 | oxidoreductase activity | 2.60E-05 | 71 | 455 |
| GO:0006457 | protein folding | 1.62E-04 | 24 | 118 |
| GO:0008610 | lipid biosynthetic process | 1.81E-04 | 27 | 134 |
| GO:0006730 | one-carbon metabolic process | 1.00E-03 | 3 | 3 |
| GO:0009116 | nucleoside metabolic process | 1.30E-03 | 23 | 124 |
(P-value cutoff of <0.05; Number of DE genes and total number of genes in each GO term are shown)