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. 2017 Oct 31;41(1):155–163. doi: 10.3892/ijmm.2017.3225

Figure 2.

Figure 2

Histone deacetylase 3 (HDAC3) loss of function suppresses growth of gastric cancer (GC) cells. (A) HDAC3 silencing significantly decreased the viability of AGS, SGS-7901 and BGC-823 cells in vitro. Cell viability was detected in GC cell lines following culture for 0, 24, 48 and 72 h. Optical density was measured at a wavelength of 450 nm. (B) HDAC3 silencing significantly downregulated gastric tumor weight in a GC mouse model induced by inoculating AGS, SGC-7901 and BGC-823 cells. (C) HDAC3 silencing markedly attenuated the colony formation capacity of AGS, SGS-7901 and BGC-823 cells. Data are presented as the means ± SEM. *p<0.05, **p<0.01 and ***p<0.001 vs. sh-cont.