Figure 10.

Effects of PD98059 on calcitriol-treated rats. (A) Western blot analysis was used to detect the expression levels of p-ERK1/2, caspase-3 and Bcl-2 in the cortex of rats at 3 days. (B) The quantitative results for p-ERK1/2 were expressed as the ratio to ERK1/2 as determined by densitometry of the western blot bands. The quantitative results of (C) caspase-3 and (D) Bcl-2 were expressed as the densitometric ratio vs. the GAPDH bands. Values are expressed as the mean ± standard error (n=5 for each group). ^*P<0.001 vs. vehicle group in (B and D); and ^*P=0.014 vs. vehicle group in (C). GCI, global cerebral ischemia; p-ERK, phosphorylated extracellular signal-regulated kinase; Bcl-2, B-cell lymphoma-2.