Table II.
Top 30 cAMP-upregulated lncRNAs and cAMP-downregulated lncRNAs reversed by metformin.
| Seqname | Fold-change | Regulation (cAMP vs. control) | Fold-change | Regulation (metformin vs. cAMP) |
|---|---|---|---|---|
| AK008754 | 63.58867 | Up | 55.04594 | Down |
| AK036023 | 57.2507 | Up | 3.325115 | Down |
| ENSMUST00000138573 | 37.43524 | Up | 2.130461 | Down |
| uc007biz.1 | 31.35165 | Up | 17.08355 | Down |
| NR_030715 | 25.00611 | Up | 45.54781 | Down |
| uc009njr.1 | 22.53223 | Up | 4.457007 | Down |
| MM9LINCRNAEXON10271− | 19.73751 | Up | 2.071386 | Down |
| ENSMUST00000129953 | 18.7799 | Up | 8.698158 | Down |
| uc008hhq.1 | 15.70811 | Up | 8.776502 | Down |
| AK133602 | 15.02128 | Up | 8.871666 | Down |
| ENSMUST00000147868 | 14.96649 | Up | 32.93101 | Down |
| AA591058 | 14.75416 | Up | 16.43587 | Down |
| uc009jlk.1 | 12.59451 | Up | 43.2916 | Down |
| AK040239 | 8.804657 | Up | 8.449728 | Down |
| AK018502 | 7.718255 | Up | 8.491624 | Down |
| ENSMUST00000166559 | 7.339848 | Up | 2.552899 | Down |
| ENSMUST00000164645 | 6.906824 | Up | 2.483507 | Down |
| uc007otm.1 | 6.888684 | Up | 6.263191 | Down |
| ENSMUST00000145208 | 6.529995 | Up | 19.36338 | Down |
| uc007idu.1 | 6.296531 | Up | 3.856799 | Down |
| AK052609 | 6.237578 | Up | 7.895747 | Down |
| CR518961 | 6.112049 | Up | 2.601747 | Down |
| ENSMUST00000137582 | 6.028889 | Up | 8.330698 | Down |
| NR_024513 | 6.003099 | Up | 10.10774 | Down |
| NR_027901 | 5.708479 | Up | 20.74246 | Down |
| ENSMUST00000130094 | 5.705397 | Up | 33.7096 | Down |
| ENSMUST00000142260 | 5.699138 | Up | 15.27239 | Down |
| ENSMUST00000161491 | 5.59761 | Up | 29.0643 | Down |
| ENSMUST00000129758 | 5.463225 | Up | 5.843725 | Down |
| NR_030782 | 5.312138 | Up | 2.623824 | Down |
| BY008479 | 21.01573 | Down | 2.650546 | Up |
| NR_033533 | 15.91963 | Down | 2.650648 | Up |
| NR_030719 | 14.39216 | Down | 3.259029 | Up |
| uc.71+ | 12.23815 | Down | 2.515803 | Up |
| ENSMUST00000119007 | 8.960969 | Down | 2.669164 | Up |
| AK018576 | 8.671295 | Down | 3.36866 | Up |
| NR_030720 | 6.8741 | Down | 4.131914 | Up |
| AK171775 | 6.527647 | Down | 2.402267 | Up |
| uc008ref.1 | 6.215065 | Down | 5.873268 | Up |
| ENSMUST00000117185 | 6.061 | Down | 3.369349 | Up |
| uc008iqy.1 | 6.043397 | Down | 3.388012 | Up |
| AA636162 | 5.986786 | Down | 2.320948 | Up |
| mouselincRNA1303+ | 5.755683 | Down | 7.49714 | Up |
| MM9LINCRNAEXON11420+ | 5.640478 | Down | 3.268149 | Up |
| ENSMUST00000152190 | 5.534303 | Down | 2.962099 | Up |
| AK148967 | 5.531486 | Down | 3.036806 | Up |
| uc007qpd.1 | 5.508539 | Down | 8.222444 | Up |
| AK140466 | 5.259056 | Down | 2.131494 | Up |
| ENSMUST00000169881 | 5.179452 | Down | 3.134108 | Up |
| uc007cua.1 | 5.058929 | Down | 3.124969 | Up |
| AI586175 | 4.876382 | Down | 4.435117 | Up |
| NR_033629 | 4.820504 | Down | 2.005511 | Up |
| AK019612 | 4.674555 | Down | 2.644345 | Up |
| mouselincRNA1040+ | 4.510026 | Down | 49.62078 | Up |
| NR_002702 | 4.507347 | Down | 4.266528 | Up |
| ENSMUST00000129609 | 4.367185 | Down | 5.31341 | Up |
| ENSMUST00000119828 | 4.262482 | Down | 11.6708 | Up |
| uc008ijm.1 | 4.213697 | Down | 4.486794 | Up |
| AK035610 | 4.009485 | Down | 2.407165 | Up |
| uc009spu.1 | 3.959393 | Down | 2.946273 | Up |
The table lists only some of the results for lncRNAs with an up- or downregulation in expression in the cAMP group compared with the control group and in the metformin group compared with the cAMP group. Seqname, lncRNA name; fold-change, absolute fold-change between the compared groups; up, upregulation; down, downregulation; cAMP, cyclic adenosine monophosphate; lncRNA, long non-coding RNA.