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. 2017 Nov 9;41(1):251–263. doi: 10.3892/ijmm.2017.3245

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of LSE on AChE (A and B) and Aβ (C and D) in the blood and the hippocampus of T2DM rats. The normal rats were treated with NS (1 ml/kg/day), and T2DM rats induced by high fat, high sugar and high protein diet and (STZ, 27 mg/kg, intraperitoneal ×1) were treated with NS (1 ml/kg/day), Don (0.42 mg/kg/day), or LSE (0.7, 1.4 and 2.8 g/kg/day, IG ×28 days). There were 10 rats used for each experimental group and are expressed as the mean ± standard deviation. ^*P<0.05 vs. T2DM rats treated with NS; ^**P<0.01 vs. T2DM rats treated with NS; ^#P<0.01 vs. LSE 0.7 g/kg group. LSE, lychee seed extract; AChE, acetylcholinesterase; NS, normal saline; STZ, streptozotocin; Don, donepezil; NS, normal saline.