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. 2017 Nov 9;41(1):251–263. doi: 10.3892/ijmm.2017.3245

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of LSE on AGEs in the hippocampus of rats. The normal rats were treated with NS (1 ml/kg/day) and type 2 diabetes mellitus rats induced by high fat, high sugar and high protein diet and STZ (27 mg/kg, intraperitoneal ×1) were treated with NS (1 ml/kg/day), Don (0.42 mg/kg/day) or LSE (0.7, 1.4 and 2.8 g/kg/day) with intragastric administration daily for 28 days. There were 10 rats used for each experimental group and results are expressed as the mean ± standard deviation. ^**P<0.01 vs. T2DM rats treated with NS. LSE, lychee seed extract; AGEs, advanced glycation end products; NS, normal saline; STZ, streptozotocin; Don, donepezil.