Table 1. Univariate and Cox proportional hazards regression analysis of factors related to progression, cancer-specific mortality, and overall survival.
| Progression | Cancer-specific mortality | Overall survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||
| Parameters | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value |
| Gender | ||||||||||||
| Male | 1 | 1 | 1 | |||||||||
| Female | 1.0 (0.8–1.2) | 0.8177 | 1.0 (0.9–1.1) | 1.0000 | 0.9 (0.8–1.1) | 0.5608 | ||||||
| Age | ||||||||||||
| <65 y.o | 1 | 1 | 1 | |||||||||
| ≥65 y.o | 1.0 (0.8–1.2) | 1.0000 | 1.0 (0.9–1.1) | 1.0000 | 1.0 (0.9–1.2) | 0.7755 | ||||||
| Stage | ||||||||||||
| I | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| ≥II | 1.3 (1.0–1.8) | 0.0164 | 3.0 (1.3–7.1) | 0.0123 | 1.2 (1.0–1.4) | 0.0267 | 1.8 (1.1–2.8) | 0.0114 | 1.2 (1.0–1.4) | 0.0428 | 3.0 (1.1–9.2) | 0.0424 |
| Fuhrman grade | ||||||||||||
| G1/2 | 1 | 1 | 1 | 1 | ||||||||
| G3/4 | 1.4 (1.0–1.9) | 0.0134 | 1.8 (0.8–4.3) | 0.1481 | 1.1 (1.0–1.3) | 0.0752 | 1.2 (0.9–1.4) | 0.1134 | ||||
| LVI | ||||||||||||
| Yes | 1 | 1 | 1 | |||||||||
| No | 1.7 (1.0–2.7) | 0.0568 | 1.9 (1.1–3.2) | 0.0856 | 1.4 (0.7–2.5) | 0.3855 | ||||||
| Exosomal-miR-224 | ||||||||||||
| Low | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| High | 1.7 (1.4–2.2) | <0.0001 | 11 (3.3–68.7) | <0.0001 | 1.2 (1.1–1.4) | 0.0027 | 1.6 (1.1–2.5) | 0.0140 | 1.3 (1.1–1.5) | 0.0009 | 9.1 (1.8–166.1) | 0.0043 |
HR, hazard ratio; CI, confidence interval; LVI, lymphovascular invasion.