Figure 3. L-Asp sensitivity of AML cell lines and primary AML cells with or without -7.

(A) AML cell lines with -7 (UCSD-AML1, FKH-1 and OCI-AML6) were more sensitive to L-Asp than AML cell lines without -7 (p = 0.003). (B) Dose-response growth curves of primary AML cells treated with L-Asp showed that AML -7 are more sensitive than other AML primary cells. Pt1: AML M4 with disomy of chromosome 7; Pt2: AML M2 with disomy of chromosome 7; Pt3: AML M2 with monosomy of chromosome 7.