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(A) Low expression of ASNS gene correlated with ASNS promoter methylation (in ALL cells) or -7 (in AML cells). Cell lines with -7 or methylation of ASNS promoter (●) have lower ASNS expression than cell lines without these genetic aberrations (■). (B) Cell lines with -7 or methylation of ASNS promoter (●) displayed higher sensitivity to L-Asp treatment than other cell lines without these genetic aberrations (■).
