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. 2017 Nov 24;8(66):110133–110144. doi: 10.18632/oncotarget.22655

Figure 4.

Figure 4

(A) Representation of somatic mitochondrial DNA variants detected only in AQR clones in MT-CO1 gene. (B) Validation of the ENST00000361624.2: c.1367T>A variant by pyrosequencing. (C) PCR verification of ρ(o) status of H1975ρ(o) cells compared with parental H1975 cells. (D) Bar charts showing IC50 values of BEZ235, PI103, KU-0063794 and carboplatin in H1975 (blue columns) and H1975ρ0 (black columns) cells. Also shown are the levels of extracellular lactate and reactive oxygen species in H1975 and H1975ρ0 cells. *p < 0.05, paired t-test.