Table 8. Stratified analyses between ALDH3B2 rs7947978 polymorphism and ESCC risk by sex, age, smoking status and alcohol consumption.
| Variable | (case/control) a | Adjusted ORb (95%CI); p | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CC | AA | CA | AA+CA | CC | AA | CA | AA+CA | AA vs. (CC+CA) | |
| Sex | |||||||||
| Male | 595/762 | 7/12 | 143/174 | 150/186 | 1.00 | 1.339 (0.52–3.42); p:0.541 | 0.950 (0.74–1.22); p:0.683 | 0.968 (0.76–1.23); p:0.792 | 0.740 (0.29–1.89); p:0.527 |
| Female | 209/292 | 5/6 | 66/64 | 71/70 | 1.00 | 0.859 (0.26–2.85); p:1.000 | 0.694 (0.47–1.02); p:0.064 | 0.706 (0.49–1.03); p:0.068 | 1.079 (0.33–3.57); p:1.000 |
| Age | |||||||||
| < 63 | 372/507 | 4/11 | 90/114 | 94/125 | 1.00 | 2.018 (0.64–6.39); p:0.295 | 0.929 (0.68–1.26); p:0.640 | 0.976 (0.72–1.32); p:0.872 | 0.489 (0.16–1.55); p:0.295 |
| ≥ 63 | 432/547 | 8/7 | 119/124 | 127/131 | 1.00 | 0.691 (0.25–1.92); p:0.476 | 0.823 (0.62–1.09); p:0.174 | 0.815 (0.62–1.07); p:0.143 | 1.392 (0.50–3.86); p:0.524 |
| Smoking status | |||||||||
| Never | 447/778 | 7/14 | 120/168 | 127/182 | 1.00 | 1.149 (0.46–2.87); p:0.766 | 0.824 (0.62–1.05); p:0.102 | 0.823 (0.64–1.06); p:0.134 | 0.834 (0.34–2.08); p:0.697 |
| Ever | 357/276 | 5/4 | 89/70 | 94/74 | 1.00 | 1.035 (0.28–3.89); p:1.000 | 1.017 (0.72–1.44); p:0.923 | 1.018 (0.72–1.44); p:0.918 | 0.970 (0.26–3.64); p:1.000 |
| Alcohol consumption | |||||||||
| Never | 552/979 | 9/17 | 142/221 | 151/238 | 1.00 | 1.065 (0.47–2.41); p:0.879 | 0.878 (0.69–1.11); p:0.276 | 0.889 (0.71–1.12); p:0.313 | 0.915 (0.41–2.07); p:0.831 |
| Ever | 252/75 | 3/1 | 67/17 | 70/18 | 1.00 | 1.120 (0.12–10.93); p:1.000 | 0.853 (0.47–1.54); p:0.597 | 0.864 (0.48–1.54); p:0.620 | 0.865 (0.09–8.42); p:1.000 |
a The genotyping success rate was 99.02% for rs7947978; b Adjusted for age, sex, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model; Fisher exact test was performed when n ≤ 5; Bonferroni correction was performed to correct the p value, bold values are statistically significant (p < 0.0125).