Table 2. Primary information for MTHFR polymorphisms (rs1801133 G>A, rs9651118 T>C rs4845882 G>A, rs4846048 A>G and rs3753584 T>C).

Genotyped SNPs	rs1801133 G>A	rs3753584 T>C	rs4845882 G>A	rs4846048 A>G	rs9651118 T>C
Chromosome	1	1	1	1	1
Function	Missense	NearGene-5	Intron	Intron	Intron
Chr Pos (Genome Build 36.3)	11778965	11787173	11765754	11768839	11784801
MAFa for Chinese in database	0.439	0.093	0.198	0.105	0.382
MAF in our controls (n = 1,030)	0.345	0.118	0.214	0.095	0.383
P value for HWEb test in our controls	0.947	0.712	0.454	0.036	0.081
Genotyping method	SNPscan	SNPscan	SNPscan	SNPscan	SNPscan
% Genotyping value	99.87%	99.94%	99.94%	99.94%	99.94%

^aMAF: minor allele frequency;

^bHWE: Hardy–Weinberg equilibrium