Table 3. Logistic regression analyses of associations between MTHFR rs1801133 G>A, rs3753584 T>C, rs4845882 G>A, rs4846048 A>G and rs9651118 T>C polymorphisms and the risk of NSCLC.
| Genotype | Cases(n = 521) | Controls(n = 1,030) | Crude OR(95%CI) | P | Adjusted OR a(95%CI) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| MTHFR rs1801133 G>A | ||||||||
| GG | 241 | 46.35 | 441 | 42.86 | 1.00 | 1.00 | ||
| GA | 235 | 45.19 | 466 | 45.29 | 0.92 (0.74–1.15) | 0.467 | 0.92 (0.73–1.16) | 0.461 |
| AA | 44 | 8.46 | 122 | 11.86 | 0.66 (0.45–0.96) | 0.031 | 0.66 (0.44–0.97) | 0.035 |
| GA + AA | 279 | 53.65 | 588 | 57.14 | 0.87 (0.70–1.07) | 0.192 | 0.87 (0.70–1.08) | 0.207 |
| GG+ GA | 476 | 91.54 | 907 | 88.14 | 1.00 | 1.00 | ||
| AA | 44 | 8.46 | 122 | 11.86 | 0.69 (0.48–0.99) | 0.042 | 0.69 (0.47–1.00) | 0.050 |
| A allele | 323 | 31.06 | 710 | 34.50 | ||||
| MTHFR rs3753584 T>C | ||||||||
| TT | 403 | 77.35 | 800 | 77.75 | 1.00 | 1.00 | ||
| CT | 111 | 21.31 | 216 | 20.99 | 1.02 (0.79–1.32) | 0.872 | 1.03 (0.79–1.35) | 0.829 |
| CC | 7 | 1.34 | 13 | 1.26 | 1.07 (0.42–2.71) | 0.885 | 1.04 (0.39–2.76) | 0.937 |
| CT+CC | 118 | 22.65 | 229 | 22.25 | 1.02 (0.80–1.32) | 0.860 | 1.03 (0.79–1.34) | 0.826 |
| TT+CT | 514 | 98.66 | 1,016 | 98.74 | 1.00 | 1.00 | ||
| CC | 7 | 1.34 | 13 | 1.26 | 1.07 (0.42–2.69) | 0.894 | 1.03 (0.39–2.74) | 0.948 |
| C allele | 125 | 12.00 | 242 | 11.76 | ||||
| MTHFR rs4845882 G>A | ||||||||
| GG | 309 | 59.31 | 632 | 61.42 | 1.00 | 1.00 | ||
| GA | 191 | 36.66 | 354 | 34.40 | 1.11 (0.89–1.38) | 0.378 | 1.12 (0.89–1.42) | 0.326 |
| AA | 21 | 4.03 | 43 | 4.18 | 1.00 (0.58–1.72 | 0.999 | 1.14 (0.65–2.01) | 0.642 |
| GA+AA | 212 | 40.69 | 397 | 38.58 | 1.09 (0.88–1.35) | 0.422 | 1.12 (0.90–1.10) | 0.308 |
| GG+GA | 500 | 95.97 | 986 | 95.82 | 1.00 | 1.00 | ||
| AA | 21 | 4.03 | 43 | 4.18 | 0.96 (0.57–1.64) | 0.891 | 1.09 (0.63–1.91) | 0.753 |
| A allele | 233 | 22.36 | 440 | 21.38 | ||||
| MTHFR rs4846048 A>G | ||||||||
| AA | 428 | 82.15 | 849 | 82.51 | 1.00 | 1.00 | ||
| AG | 90 | 17.27 | 165 | 16.03 | 1.08 (0.82–1.44) | 0.578 | 1.13 (0.84–1.51) | 0.423 |
| GG | 3 | 0.58 | 15 | 1.46 | 0.40 (0.11–1.38) | 0.146 | 0.48 (0.13–1.73) | 0.264 |
| AG+GG | 93 | 17.85 | 180 | 17.49 | 1.03 (0.78–1.35) | 0.861 | 1.08 (0.81–1.44) | 0.609 |
| AA+AG | 518 | 99.42 | 1,014 | 98.54 | 1.00 | 1.00 | ||
| GG | 3 | 0.58 | 15 | 1.46 | 0.39 (0.11–1.36) | 0.140 | 0.47 (0.13–1.70) | 0.250 |
| G allele | 96 | 9.21 | 195 | 9.48 | ||||
| MTHFR rs9651118 T>C | ||||||||
| TT | 187 | 35.89 | 378 | 36.73 | 1.00 | 1.00 | ||
| TC | 245 | 47.02 | 513 | 49.85 | 0.97 (0.77–1.22) | 0.783 | 0.94 (0.74–1.20) | 0.636 |
| CC | 89 | 17.08 | 138 | 13.41 | 1.31 (0.95–1.80) | 0.100 | 1.30 (0.93–1.81) | 0.124 |
| TC+CC | 334 | 64.11 | 651 | 63.27 | 1.04 (0.83–1.29) | 0.745 | 1.02 (0.81–1.28) | 0.895 |
| TT+TC | 432 | 82.92 | 891 | 86.59 | 1.00 | 1.00 | ||
| CC | 89 | 17.08 | 138 | 13.41 | 1.33 (1.00–1.78) | 0.054 | 1.34 (0.99–1.82) | 0.057 |
| C allele | 423 | 40.60 | 789 | 38.34 | ||||
a Adjusted for age, sex, smoking, BMI and drinking status; Bold values are statistically significant (P < 0.05).