Table 4. Stratified analyses between MTHFR rs1801133 G>A polymorphism and NSCLC risk by sex, age, BMI, smoking status and alcohol consumption.

Variable	MTHFR rs1801133 G>A (case/control)a			Adjusted ORb (95% CI); P
	GG	GA	AA	GG	GA	AA	GA /AA	AA vs. (GA/GG)
Sex
Male	125/254	136/275	25/58	1.00	0.99 (0.72–1.35);P: 0.930	0.83 (0.48–1.45);P: 0.518	0.97 (0.71–1.32);P: 0.840	0.84 (0.50–1.43);P: 0.527
Female	116/187	99/191	19/64	1.00	0.85 (0.61–1.20);P: 0.357	0.53 (0.30–0.94);P: 0.031	0.78 (0.56–1.07);P: 0.126	0.58 (0.33–1.00);P: 0.048
Age
< 60	125/213	97/213	16/49	1.00	0.79 (0.56–1.12);P: 0.187	0.53 (0.28–1.00);P: 0.048	0.74 (0.53–1.03);P: 0.072	0.59 (0.32–1.09);P: 0.090
≥ 60	116/228	138/253	28/73	1.00	1.05 (0.77–1.44);P: 0.759	0.78 (0.47–1.30);P: 0.344	1.01 (0.74–1.36);P: 0.976	0.77 (0.47–1.24);P: 0.276
Smoking status
Never	153/352	137/372	26/103	1.00	0.86 (0.65–1.14);P: 0.298	0.58 (0.36–0.93);P: 0.024	0.81 (0.62–1.05);P: 0.112	0.62 (0.39–0.99);P: 0.044
Ever	88/89	98/94	18/19	1.00	1.06 (0.70–1.60);P: 0.786	0.92 (0.45–1.90);P: 0.829	1.04 (0.70–1.54);P: 0.861	0.90 (0.45–1.78);P: 0.754
Alcohol consumption
Never	210/411	197/426	36/111	1.00	0.93 (0.72–1.19);P: 0.543	0.68 (0.44–1.03);P: 0.071	0.88 (0.70–1.12);P: 0.293	0.71 (0.47–1.06);P: 0.092
Ever	31/30	38/40	8/11	1.00	0.88 (0.44–1.75);P: 0.711	0.60 (0.21–1.75);P: 0.353	0.82 (0.42–1.58);P: 0.550	0.65 (0.24–1.75);P: 0.393
BMI (kg/m2)
< 24	159/242	151/247	27/57	1.00	0.94 (0.70–1.27);P: 0.699	0.68 (0.41–1.15);P: 0.149	0.89 (0.67–1.19);P: 0.427	0.70 (0.43–1.16);P: 0.164
≥ 24	82/199	84/219	17/65	1.00	0.88 (0.61–1.27);P: 0.490	0.64 (0.35–1.17);P: 0.147	0.84 (0.59–1.19);P: 0.323	0.69 (0.38–1.23);P: 0.203

^a The genotyping was successful in 521 (99.81%) NSCLC cases, and 1030 (99.90%) controls for MTHFR rs1801133 G>A;

^b Adjusted for age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model;