Table 5. Stratified analyses between MTHFR rs3753584 T>C polymorphism and NSCLC risk by sex, age, BMI, smoking status and alcohol consumption.

Variable	MTHFR rs3753584 T>C (case/control)a			Adjusted ORb (95% CI); P
	TT	TC	CC	TT	TC	CC	TC / CC	CC vs. (TC/TT)
Sex
Male	231/450	52/127	4/10	1.00	0.80 (0.54–1.17);P: 0.242	0.68 (0.20–2.32);P: 0.533	0.78 (0.54–1.14);P: 0.201	0.71 (0.21–2.42);P: 0.578
Female	172/350	59/89	3/3	1.00	1.35 (0.92–1.97);P: 0.128	2.51 (0.479–12.75);P: 0.268	1.38 (0.95–2.01);P: 0.093	2.34 (0.46–11.88);P: 0.304
Age
< 60	181/362	54/110	3/3	1.00	0.95 (0.65–1.40);P: 0.806	1.30 (0.25–6.67);P: 0.756	0.96 (0.66–1.41);P: 0.848	1.31 (0.26–6.73);P: 0.745
≥ 60	222/438	57/106	4/10	1.00	1.12 (0.77–1.63);P: 0.560	0.89 (0.26–3.04);P: 0.855	1.10 (0.76–1.58);P: 0.610	0.87 (0.26–2.97);P: 0.827
Smoking status
Never	240/650	73/168	4/9	1.00	1.16 (0.84–1.60);P: 0.359	1.48 (0.44–5.00);P: 0.528	1.18 (0.86–1.61);P: 0.314	1.43 (0.43–4.83);P: 0.562
Ever	163/150	38/48	3/4	1.00	0.77 (0.47–1.25);P: 0.281	0.66 (0.14–3.02);P: 0.593	0.76 (0.47–1.21);P: 0.247	0.70 (0.15–3.20);P: 0.645
Alcohol consumption
Never	341/735	96/202	7/11	1.00	0.99 (0.74–1.32);P: 0.937	1.43 (0.52–3.92);P: 0.489	1.01 (0.76–1.33);P: 0.951	1.43 (0.52–3.92);P: 0.486
Ever	62/65	15/14	0/2	1.00	1.31 (0.56–3.07);P: 0.537	-	1.08 (0.48–2.45);P: 0.852	-
BMI (kg/m2)
< 24	265/432	69/105	3/9	1.00	1.04 (0.73–1.48);P: 0.830	0.47 (0.12–1.84);P: 0.278	0.99 (0.70–1.40);P: 0.960	0.47 (0.12–1.82);P: 0.272
≥ 24	138/368	42/111	4/4	1.00	0.99 (0.65–1.50);P: 0.946	3.34 (0.80–14.04);P: 0.100	1.06 (0.70–1.59);P: 0.788	3.35 (0.80–14.04);P: 0.098

^a The genotyping was successful in 521 (100.00%) NSCLC cases, and 1030 (99.90%) controls for MTHFR rs3753584 T>C;

^b Adjusted for age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model;