Table 7. Stratified analyses between MTHFR rs4846048 A>G polymorphism and NSCLC risk by sex, age, BMI, smoking status and alcohol consumption.

Variable	MTHFR rs4846048 A>G (case/control)a			Adjusted ORb (95% CI); P
	AA	AG	GG	AA	AG	GG	AG/GG	GG vs. (AG/AA)
Sex
Male	233/488	51/88	3/11	1.00	1.29(0.86-1.94);P: 0.221	0.68(0.18-2.64);P: 0.576	1.22(0.83-1.81);P: 0.314	0.65(0.17-2.52);P: 0.535
Female	195/361	39/77	0/4	1.00	0.97(0.63-1.49);P: 0.884	-	0.92(0.60-1.41);P: 0.701	-
Age
< 60	191/393	47/74	0/8	1.00	1.45(0.95-2.22);P: 0.088	-	1.32(0.87-2.00);P: 0.197	-
≥ 60	237/456	43/91	3/7	1.00	0.88(0.59-1.33);P: 0.555	0.94(0.23-3.86);P: 0.936	0.89(0.60-1.32);P: 0.558	0.96(0.24-3.93);P: 0.959
Smoking status
Never	262/676	53/140	2/11	1.00	0.98(0.69-1.40);P: 0.925	0.60(0.13-2.79);P: 0.512	0.96(0.68-1.36);P: 0.810	0.60(0.13-2.79);P: 0.513
Ever	166/173	37/25	1/4	1.00	1.54(0.89-2.68);P: 0.126	0.31(0.03-2.87);P: 0.302	1.39(0.81-2.36);P: 0.230	0.29(0.03-2.67);P: 0.274
Alcohol consumption
Never	366/779	76/156	2/13	1.00	1.06(0.77-1.45);P: 0.723	0.41(0.09-1.89);P: 0.254	1.01(0.75-1.38);P: 0.931	0.41(0.09-1.87);P: 0.248
Ever	62/70	14/9	1/2	1.00	1.95(0.77-4.96);P: 0.162	0.57(0.05-7.23);P: 0.664	1.70(0.71-4.09);P: 0.238	0.52(0.04-6.52);P: 0.610
BMI(kg/m2)
< 24	281/455	55/86	1/5	1.00	1.10(0.75-1.62);P: 0.629	0.55(0.06-4.92);P: 0.591	1.08(0.74-1.57);P: 0.708	0.54(0.06-4.83);P: 0.579
≥ 24	147/394	35/79	2/10	1.00	1.20(0.76-1.89);P: 0.433	0.41(0.08-2.02);P: 0.274	1.10(0.71-1.71);P: 0.678	0.40(0.08-1.96);P: 0.258

^aThe genotyping was successful in 521 (100.00%) NSCLC cases, and 1030 (99.90%) controls for MTHFR rs4846048 A>G;

^bAdjusted for age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.