Table 8. Stratified analyses between MTHFR rs9651118 T>C polymorphism and NSCLC risk by sex, age, BMI, smoking status and alcohol consumption.

Variable	MTHFR rs9651118 T>C (case/control)a			Adjusted ORb (95% CI); P
	TT	TC	CC	TT	TC	CC	TC / CC	CC vs. (TC/TT)
Sex
Male	110/209	133/300	44/78	1.00	0.85 (0.61–1.18);P: 0.330	1.11 (0.69–1.76);P: 0.676	0.90 (0.66–1.23);P: 0.503	1.21 (0.79–1.86);P: 0.381
Female	77/169	112/213	45/60	1.00	1.05 (0.73–1.51);P: 0.794	1.48 (0.92–2.39);P: 0.109	1.15 (0.81–1.61);P: 0.435	1.44 (0.94–2.22);P: 0.098
Age
<60	82/163	110/255	46/57	1.00	0.90 (0.62–1.29);P: 0.549	1.64 (1.00–2.69);P: 0.049	1.03 (0.73–1.45);P: 0.868	1.75 (1.12–2.74);P: 0.014
≥60	105/215	135/258	43/81	1.00	1.00 (0.72–1.39);P: 1.00	1.05 (0.66–1.65);P: 0.848	1.01 (0.74–1.38);P: 0.946	1.05 (0.69–1.59);P: 0.834
Smoking status
Never	111/305	146/412	60/110	1.00	0.93 (0.69–1.25);P: 0.646	1.45 (0.98–2.14);P: 0.066	1.04 (0.79–1.37);P: 0.791	1.50 (1.05–2.14);P: 0.025
Ever	76/73	99/101	29/28	1.00	0.95 (0.62–1.46);P: 0.819	0.97 (0.52–1.80);P: 0.918	0.96 (0.64–1.44);P: 0.824	1.00 (0.56–1.76);P: 0.989
Never	159/340	205/479	80/129	1.00	0.87 (0.67–1.13);P: 0.296	1.25 (0.88–1.78);P: 0.212	0.95 (0.74–1.21);P: 0.677	1.35 (0.99–1.86);P: 0.062
Ever	28/38	40/34	9/9	1.00	1.66 (0.83–3.30);P: 0.153	1.45 (0.49–4.24);P: 0.501	1.61 (0.83–3.11);P: 0.155	1.11 (0.40–3.03);P: 0.845
BMI (kg/m2)
< 24	108/187	165/287	64/72	1.00	0.99 (0.72–1.36);P: 0.967	1.56 (1.01–2.39);P: 0.044	1.10 (0.81–1.49);P: 0.532	1.56 (1.06–2.29);P: 0.023
≥ 24	79/191	80/226	25/66	1.00	0.85 (0.58–1.25);P: 0.406	0.95 (0.55–1.64);P: 0.850	0.87 (0.61–1.25);P: 0.456	1.03 (0.62–1.72);P: 0.908

^aThe genotyping was successful in 521 (100.00%) NSCLC cases, and 1030 (99.90%) controls for MTHFR rs9651118 T>C;

^bAdjusted for age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model;