Table 1. Summary of virology and pathology results.

To compare changes of identity, divergence of full genome sequence, and histology between CVB2 strains, the following was undertaken. Mice were inoculated intraperitoneally with 2.5 × 10⁴ PFU/0.5 mL (PFU, plaque-forming unit) of a CVB2 strain to reveal histopathological changes in their heart and pancreas on days 7and 13 post-inoculation (pi). In addition, percentages of identity and divergence of homology of genome sequences between the CB2 reference strain (CVB/O) and the Korean isolates, which differed in clinical signs, were compared. The sequences of Korean isolate strains CB2/04/279 and CB2/04/243 had a high degree of homology in contrast, strains CB2/04/279 and CVB/O exhibited highly similar patterns of histological change in mice. Positive (+) and negative (−) of the histological lesion in mice group. ^*Percent nucleotide sequence identity between full genomes of two CB2 strains. ^†Percent nucleotide sequence divergence between full genomes of two CB2 strains.