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Comparison between the linear maturation and lineage differentiation models of iNKT cell development. Invariant TCR-expressing thymocytes are positively selected by CD1d+ cortical thymocytes. In the linear maturation model, NKT cells that produce IL-4 or IL-17 are considered immature, while mature cells produce IFN-γ. In the lineage differentiation model, undifferentiated PLZFhigh NKTp give rise to terminally differentiated NKT1, NKT2, and NKT17 cells.
