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Schematic representation of iNKT cell development and localization in the thymus. Upon positive selection, NKTp cells move to the medullary area and undergo differentiation into various subsets. NKT2 cells produce IL-4 at steady state, which can condition medullary thymocytes to phosphorylate STAT6 and express Eomes. A portion of NKT1 and NKT17 cells migrate back to the cortical area.
STAT6, signal transducer and activator of transcription 6.
