Table 2. Association with LATS1 expression and clinicopathological factors.
| Variables | Cases | LATS1 expression | P-value | ||
|---|---|---|---|---|---|
| Low | High | ||||
| Total | 264 | 60 (22.7) | 204 (77.3) | ||
| Sex | 0.706 | ||||
| Male | 184 | 43 (71.7) | 141 (69.1) | ||
| Female | 80 | 17 (28.3) | 63 (30.9) | ||
| Age | 0.384 | ||||
| <65 | 141 | 35 (58.3) | 106 (52.0) | ||
| ≥65 | 123 | 25 (41.7) | 98 (48.0) | ||
| Location | 0.633 | ||||
| Upper | 36 | 9 (15.0) | 27 (13.2) | ||
| Middle | 36 | 6 (10.0) | 30 (14.7) | ||
| Lower | 192 | 45 (75.0) | 147 (72.1) | ||
| AJCC stage | 0.001 | ||||
| I/II | 165 | 27 (45.0) | 138 (67.6) | ||
| III/IV | 99 | 33 (55.0) | 66 (32.4) | ||
| Tumor depth | 0.032 | ||||
| T1/T2 | 142 | 25 (41.7) | 117 (57.4) | ||
| T3/T4 | 122 | 35 (58.3) | 87 (42.6) | ||
| LN metastasis | 0.040 | ||||
| Absent | 132 | 23 (38.3) | 109 (53.4) | ||
| Present | 132 | 37 (61.7) | 95 (46.6) | ||
| Distant metastasis | 0.876 | ||||
| Absent | 256 | 58 (96.7) | 198 (97.1) | ||
| Present | 8 | 2 (3.3) | 6 (2.9) | ||
| Lymphatic invasion | 0.061 | ||||
| Absent | 138 | 25 (41.7) | 113 (55.4) | ||
| Present | 126 | 35 (58.3) | 91 (44.6) | ||
| Vascular invasion | 0.676 | ||||
| Absent | 237 | 53 (88.3) | 184 (90.2) | ||
| Present | 27 | 7 (11.7) | 20 (9.8) | ||
| Perineural invasion | 0.042 | ||||
| Absent | 198 | 39 (65.0) | 159 (77.9) | ||
| Present | 66 | 21 (35.0) | 45 (22.1) | ||
| Histologic grade | 0.007 | ||||
| WD/MD | 101 | 14 (23.3) | 87 (42.6) | ||
| PD/other | 163 | 46 (76.7) | 117 (57.4) | ||
| Lauren classification | 0.033 | ||||
| Intestinal | 102 | 17 (28.3) | 85 (41.7) | ||
| Diffuse | 154 | 43 (71.7) | 111 (54.4) | ||
| Mixed | 8 | 0 (0) | 8 (3.9) | ||
Values are presented as number only or number (%).
LATS = large tumor suppressor; AJCC = American Joint Committee on Cancer; LN = lymph node; WD = well differentiated; MD = moderately differentiated; PD = poorly differentiated.