Table 4. Univariate and multivariate analysis of factors in patients with gastric cancer by Cox regression analysis.

Parameters	Overall survival
	Univariate analysis	Multivariate analysis
	P-value	Hazard ratio (95% CI)	P-value
Gender (female vs. male)	0.302	0.980 (0.586–1.638)	0.938
Age (<65 vs. ≥65)	0.021	1.688 (1.052–2.709)	0.030
Tumor depth (T1/T2 vs. T3/T4)	<0.001	8.314 (2.973–23.247)	<0.001
LN metastasis (absent vs. present)	<0.001	1.510 (0.511–4.460)	0.456
Distant metastasis (absent vs. present)	<0.001	3.016 (1.356–6.709)	0.007
Histologic grade (WD/MD vs. PD/other)	0.002	1.071 (0.407–2.820)	0.890
Lauren classification (intestinal vs. diffuse/mixed)	0.003	1.535 (0.572–4.119)	0.395
Lymphatic invasion (absent vs. present)	<0.001	2.363 (0.905–6.170)	0.079
Vascular invasion (absent vs. present)	<0.001	1.784 (1.051–3.030)	0.032
Perineural invasion (absent vs. present)	<0.001	2.735 (1.572–4.761)	<0.001
LATS1 expression (high vs. low)	0.038	1.039 (0.638–1.691)	0.879
LATS2 expression (high vs. low)	0.038	0.586 (0.306–1.119)	0.105

LATS = large tumor suppressor; LN = lymph node; WD = well differentiated; MD = moderately differentiated; PD = poorly differentiated; CI = confidence interval.