Table 3.
Reported bronchodilator responsiveness in young healthy and wheezy children using forced oscillation technique since 2005
| Ref. | Ethnic group age, yr | n | Variable | Dose | Waiting time (n) | Absolute BDR | Relative BDR, (%) |
| Thamrin et al[53], 2007 | Healthy Caucasian (3-7) | 78 | Rrs 6,8,10 Xrs 6,8,10 | Salbutamol 600 mg | 15 | Rrs 6 -35.0, -3.1 Rrs 8 -35.0, -4.4 Rrs 10 -32.3, -3.7 Xrs 6 -0.27, 1.66 Xrs 8 - 0.04, 1.82 Xrs 10 -0.00, 2.03 | Rrs 6: 42% Rrs 8: 37% Rrs 10: 39% Xrs 6: 61% Xrs 8: 67% Xrs 10: 63% |
| Thamrin et al[53], 2007 | Asthmatics Caucasian (3-7) | 57 | Rrs 6, 8, 10 Xrs 6, 8, 10 | Salbutamol 600 µg | 15 | Rrs 6 -37.0, 8.8 Rrs8 -33.1, 9.7 Rrs 10 -33.4, 4.5 Xrs 6 -0.21, 2.30 Xrs 8 -0.13, 2.47 Xrs 10 -0.12, 2.22 | Rrs 6: 42% Rrs 8: 37% Rrs 10: 39% Xrs 6: 61% Xrs 8: 67% Xrs 10: 63% |
| Lan Vu et al[39], 2008 | Healthy Vietnamese (6–11) | 175 | Rrs 8 Hz Xrs 8 Hz | Salbutamol 200 µg | 5 | Rrs 8 -11.8,13.4 Xrs 8 4.09, - 5.78 | Rrs 8: 38% Xrs 8: 16% |
| Lan Vu et al[40], 2010 | Asthmatic Vietnamese (6-10) | 103 | Rrs 8 Hz Xrs 8 Hz | Salbutamol 200 µg | 5 | -- | Rrs 8: 13% Xrs: 32% |
| Oostveen et al[55], 2010 | Asthmatic Belgian -4 | 313 | Rrs 4 | Salbutamol 200 µg | 15 | -- | Rrs 4: 22% AX: 15.77% |
| Calogero et al[41], 2010 | Healthy Italian (3-6) | 163 | Rrs 8 Xrs8 | Salbutamol 200 µg | 15 | -- | Rrs 8: 35% Xrs 8: 34%-61% |
| LEE et al[57], 2012 | Healthy Korean | 161 | Rrs 5, 10, 15, 20, 25, 35 Xrs 5, 10, 15, 20, 25, 35 | Salbutamol 200 µg | 15 | Rrs 5 -0.127 Rrs 10 -0.098 Rrs 15 -0.073 Rrs 20 -0.056 Rrs 25 -0.056 Rrs 35 -0.057 Xrs 5 0.062 Xrs 10 0.057 Xrs 15 0.059 Xrs 20 0.044 Xrs 25 0.033 Xrs 35 0.054 Fres -2.167 | Rrs 5: 11.8 Rrs 10: 10.8 Rrs 15: 8.7 Rrs 20: 6.972 Rrs 25: 7.029 Rrs 35: 6.095 Xrs 5: 13.474 Xrs 10: 25.946 Fres: 10.457 |
| Calogero et al[43], 2013 | Healthy Australian and Italian (2-16) | 502 | Rrs 6, 8, 10 Xrs 6, 8, 10 Fres, AX | Salbutamol 200 µg | 15 | Rrs 6 -2.9 Rrs 8 -2.74 Rrs 10 -2.39 Xrs 6 -1.80 Xrs 8 - 1.93 Xrs 10 -1.90 AX -33 Fres -12 | Rrs 6: 34 Rrs 8: 32 Rrs 10: 31 Xrs 6: 50 Xrs 8: 65 Xrs 10: 74 AX: 81 Fres: 47 |
BDR: Bronchodilator responsiveness; Rrs: Respiratory system resistance; Xrs: Respiratory system reactance in hPa/s per L; Fres: Resonant frequency; AX: Area under the Xrs curve from 5 Hz to Fres; MF: Multi-frequency system; Fdep: Frequency dependence of Rrs between 4-24 Hz.