Table 5.
National Comprehensive Cancer Network (NCCN) 2017 Guidelines for Risk Factors for Recurrence for basal cell carcinoma (BCC) and Recurrence and Metastasis for squamous cell carcinomas (SCC) [106].
| Low-Risk | High-Risk | |
|---|---|---|
| BCC | ||
| Location/size | L < 20 mm M < 10 mm |
L > 20 mm M ≥ 10 mm H |
| Borders | Well Defined | Poorly Defined |
| Primary vs. Recurrent | Primary | Recurrent |
| Immunosuppression | (−) | (+) |
| Site of Prior RT | (−) | (+) |
| Pathology Subtype Perineural Involvement |
Nodular Superficial (−) |
Aggressive Growth Pattern (+) |
| SCC | ||
| Location/size | L < 20 mm M < 10 mm |
L > 20 mm M ≥ 10 mm H |
| Borders | Well Defined | Poorly Defined |
| Primary vs. Recurrent | Primary | Recurrent |
| Immunosuppression | (−) | (+) |
| Site of Prior RT or Chronic Inflammatory Process | (−) | (+) |
| Rapidly Growing Tumor | (−) | (+) |
| Neurologic Symptoms | (−) | (+) |
| Pathology Degree of Differentiation Adenoid, Adenosquamous, Desmoplastic, Metaplastic |
Well or Moderately Differentiated (−) |
Poorly Differentiated (+) |
| Depth, Thickness or Clark Level | <2 mm or I, II, III | ≥2 mm or IV, V |
| Perineural, Lymphatic, or Vascular Involvement | (−) | (+) |