Table 3. Coupling of Different Fluorinated Boronic Acids to 2,3,5,6-Tetrafluoroiodo-benzene.
Reactions were performed with 1 equiv. 1 and the corresponding boronic acid and 2.2 equiv of Na2CO3 with 5 mol % Pd2(dba)3 and a 15 mol % of the corresponding ligand at 95 °C for 60 h on a 0.18 mmol scale.
Contains significant amounts of a homocoupling side product (>2%).