Table 1. Selectivity Profile of mPTPA Inhibitor 2 against a Panel of Human PTPs, mPTPB, and a Cysteine Protease.

enzyme class	enzyme	IC50 (μM)a	selectivity
phosphatases	mPTPA	0.53 ± 0.10
	mPTPB	>100	>100
	STEP	6.2 ± 2.9	12
	LMW-PTP	43 ± 11	81
	PTP1B	50 ± 20	94
	CD45	>100	>100
	LAR	>100	>100
	TC-PTP	>100	>100
cysteine protease	cathepsin B	>100	>100

^aIC₅₀ values were determined in the presence of a physiological intracellular concentration of GSH (1 mM).