Table 1. Scope of Biocatalytic Macrocycle Oxidation^a.

^aR groups are depicted by the letters a–e shown at bottom. Major product is depicted in the table. Unless otherwise noted, percent yield refers to conversion to monohydroxylated products in preparative experiments, and ratios of monohydroxylated products are given in parentheses. Products 5b and 12b were evaluated in analytical scale experiments with comparison to authentic standards. Analysis of the identity of minor products is provided in the Supporting Information.