Table 1.
Correlations between characteristics of nucleoli in malignant melanocytes and clinical parameters
| Clinical parameters | Characteristics of nucleoli | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Size | Presence | Number | |||||||
| Low | High | p value | Low | High | p value | Low | High | p value | |
| Age in years (21–79)a
mean, 57 ± 15.4; median, 58 |
0.463 | 0.883 | 0.480 | ||||||
| Genderb | |||||||||
| Female | 46 | 11 | 0.618 | 25 | 32 | 0.532 | 42 | 15 | 0.464 |
| Male | 29 | 10 | 20 | 19 | 32 | 7 | |||
| Primary tumor locationc | |||||||||
| Head/neck | 10 | 4 | 0.927 | 5 | 9 | 0.295 | 11 | 3 | 0.722 |
| Extremities | 33 | 8 | 20 | 21 | 30 | 11 | |||
| Hand/ft | 2 | 1 | 0 | 3 | 3 | 0 | |||
| Trunk | 30 | 8 | 20 | 18 | 30 | 8 | |||
| Primary tumor (pT)a | |||||||||
| pT1 | 28 | 6 | 0.022 | 21 | 13 | 0.025 | 27 | 7 | 0.233 |
| pT2 | 17 | 0 | 10 | 7 | 15 | 2 | |||
| pT3 | 15 | 9 | 6 | 18 | 15 | 9 | |||
| pT4 | 15 | 6 | 8 | 13 | 17 | 4 | |||
| Regional lymph nodes status (pN)b | |||||||||
| No metastases (pN-) | 64 | 17 | 0.735 | 38 | 43 | 1.000 | 64 | 17 | 0.326 |
| Metastases present (pN+) | 11 | 4 | 7 | 8 | 10 | 5 | |||
| Distant metastases (pM)b | |||||||||
| No metastases (pM-) | 71 | 20 | 1.000 | 44 | 48 | 0.363 | 72 | 19 | 0.076 |
| Metastases present (pM+) | 4 | 1 | 1 | 4 | 2 | 3 | |||
| Sentinel lymph node biopsy status (SNLB)b (55 patients) | |||||||||
| No metastases (SNLB-) | 37 | 8 | 1.000 | 23 | 22 | 1.000 | 37 | 8 | 1.000 |
| Metastases present (SNLB+) | 8 | 2 | 5 | 5 | 8 | 2 | |||
| Recurrenceb | |||||||||
| No | 64 | 18 | 1.000 | 39 | 43 | 0.778 | 63 | 19 | 1.000 |
| Yes | 11 | 3 | 6 | 8 | 11 | 3 | |||
a p value of Wilcoxon two sample test
b p value of Fisher’s exact test
c p value of chi2 test;
Statistically significant results (P < 0.05) are in bold text