Table 2.

Correlations between characteristics of nucleoli and presence of intranuclear vacuoles in malignant melanocytes and histopathological parameters

Histopathological parameters	Characteristics of nucleoli
	Size			Presence			Number
	Low	High	p value	Low	High	p value	Low	High	p value
Breslow thicknessa
≤ 1 mm	28	6	0.022	21	13	0.025	27	7	0.233
1.01–2.00 mm	17	0		10	7		15	2
2.01–4.00 mm	15	9		6	18		15	9
> 4 mm	15	6		8	13		17	4
Clark levela
II and III	55	8	0.003	35	28	0.032	48	15	0.806
IV and V	20	13		10	23		26	7
Histologic typeb			0.316			0.012			0.511
Superficial spreading melanoma (SSM)	53	11		36	28		50	14
Nodular malignant melanoma (NMM)	20	9		9	20		21	8
Acral-lentiginous melanoma (ALM)	2	1		0	3		3	0
Mitotic ratea
0	40	4	0.006	28	16	0.004	37	7	0.152
≥ 1	35	17		17	35		37	15
Ulcerationc
No	46	6	0.012	31	21	0.008	45	7	0.026
Yes	29	15		14	30		29	15
TILs
No	14	3		4	13		13	4	0.585
Non-brisk	24	7	0.887	13	18	0.038	22	9
Brisk	37	11		28	20		39	9
Microsatellitosisc
No	74	17	0.008	44	47	0.363	73	18	0.010
Yes	1	4		1	4		1	4
Lymphatic invasion
No	55	16	1.000	36	35	0.248	58	13	0.098
Yes	20	5		9	16		16	9
Tumor regressionc
No	71	18	0.340	42	47	1.000	69	20	1.000
Yes	4	3		3	4		5	2

^a p value of Wilcoxon two sample test

^b p value of chi² test

^c p value of Fisher’s exact test;

Statistically significant results (P < 0.05) are in bold text