Table 2.

In vitro activity of 14 antimicrobial agents against 881 isolates of Streptococcus pneumoniae

Antimicrobial agent	PSSP (n = 318)				PISP (n = 108)				PRSP (n = 455)				P
	R%	MIC50	MIC90	MIC range	R%	MIC50	MIC90	MIC range	R%	MIC50	MIC90	MIC range
Penicillin (oral)	0	0.016	0.032	.004–.064	0	1	1	.125–1	100	4	4	2–64-	–
Amoxicillin/clavulanic acid	0.3	0.016	0.032	.008–32	0	1	2	.008–2	60.7	8	16	.016–128	<  0.00001
Ceftriaxone (non meningitis)	0	0.016	0.064	.016–1	0.9	0.5	1	.016–4	40.7	2	8	.25–512	–
Cefuroxime oral	0.6	0.032	0.125	.016–8	45.4	2	4	.016–32	97.8	16	32	.008–512	< 0.00001
Cefaclor	2.2	1	2	.016–32	88.9	128	256	1–512-	99.8	>256	>256	2–512-	< 0.00001
Vancomycin	0	0.25	0.25	.008–.5	0	0.25	0.5	.064–.5	0	0.25	0.25	.064–1	–
Erythromycin	89	16	>256	.016–512	96.3	32	>256	.032–512	99.3	>256	>256	.032–512	< 0.00001
Azithromycin	94.6	32	>256	.016–512	94.4	32	>256	.032–512	99.3	>256	>256	.032–512	0.135
Clarithromycin	88.3	32	>256	.016–512	80.6	32	>256	.016–512	98.6	>256	>256	.032–512	0.063
Tetracycline	84.6	32	64	.064–128	92.6	16	64	.25–64	97.1	32	64	.25–128	< 0.00001
Levofloxacin	1.3	1	1	.025–32	5.6	1	1	.25–32	2	1	1	.5–64	0.163
Moxifloxacin	0.6	0.125	0.25	.016–16	1.9	0.125	0.25	.016–8	0.7	0.125	0.25	.016–16	0.666
Trimethoprim/sulfamethoxazole	34.9	0.5	8	.032–64	60.2	4	8	.064–32	89.5	8	16	.125–128	< 0.00001
Clindamycin	74.2	128	256	.016–512	88	128	256	.016–256	97.8	256	256	.016–512	< 0.00001