Skip to main content
. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Sep 9;234(23-24):3455–3465. doi: 10.1007/s00213-017-4731-5

Figure 2.

Figure 2

Discriminative stimulus effects of cocaine, d-methamphetamine (d-MA), d-amphetamine (d-AMPH), l-methamphetamine (l-MA), PAL-329, and PAL-169 in rhesus monkeys (n=4) trained to discriminate cocaine (0.4 mg/kg i.m.). Abscissae: Drug dose in mg/kg (log-scale). Top ordinates: percentage cocaine-like responding for the entire component. Bottom ordinates: rate of responding expressed as responses/second. Data are Mean +/− SEM for the group of monkeys from the pretreatment time that elicited peak cocaine-like responding for each drug and are presented as mean +/− SEM for the group. Cocaine 10-min pretreatment, d-MA 30-min pretreatment, d-AMPH 10-min pretreatment, l-MA 10-min pretreatment, PAL-329 30-min pretreatment, and PAL-169 30-min pretreatment. Substitution data was excluded for two subjects following 1.0 mg/kg cocaine and 5.6 mg/kg PAL-169, and one subject for 3.2 mg/kg PAL-169 because rate of responding was significantly suppressed (<0.2 responses/sec).