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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Sep 9;234(23-24):3455–3465. doi: 10.1007/s00213-017-4731-5

Figure 6.

Figure 6

Effects of pretreatment with PAL-329, l-methamphetamine, and PAL-169 on the discriminative stimulus effects of cocaine (0.032-0.32 mg/kg) in rhesus monkeys (n=4). Abscissae: Cumulative cocaine dose in mg/kg (log-scale), C = control injections of each drug dose from corresponding pretreatment times from time-course data. Top ordinates: percentage cocaine-like responding for the entire component. Bottom ordinates: rate of responding expressed as responses/second. Substitution data from one subject was excluded from 3.2 mg/kg PAL-169 (cocaine doses 0.1–0.32 mg/kg) and from 10.0 mg/kg PAL-329 (cocaine dose 0.32 mg/kg) because rate of responding was significantly suppressed (<0.2 responses/sec).