. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: Psychopharmacology (Berl). 2017 Sep 9;234(23-24):3455–3465. doi: 10.1007/s00213-017-4731-5

Table 1.

EC₅₀ values (nM +/− SD) for monoamine releasers to release norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in in vitro rat synaptosomes. PAL-329 selectivity was approximated using 10,000 nM as the potency for 5-HT release. ^a Rothman and Baumann, 2003

Drug	EC₅₀ values			Ratio

	DA	NE	5-HT	DA/NE	5-HT/NE	5-HT/DA
d-amphetamine^a	24.8 ± 3.5	7.07 ± 0.95	1765 ± 94	3.4	245	71
d-methamphetamine^a	24.5 ± 2.1	12.3 ± 0.7	736 ± 45	1.9	59.8	30

PAL-329	1355 ± 74	106 ± 37	>10000	12.8	--	--
l-methamphetamine^a	416 ± 20	28.5 ± 2.5	4640 ± 243	14.6	162	11
PAL-169	542 ± 43	39.1 ± 5	175 ± 13	13.9	4.5	0.3