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ED80 estimates (95% C.L.) and relative potency for substitution with peak pretreatment time for cocaine and monoaminergic releasers. n=4.
| Drug (peak time) | ED80(mg/kg) | Relative Potency |
|---|---|---|
| Cocaine (10 min) | 0.16 (0.10–0.27) | 1 |
| d-AMPH (10 min) | 0.14 (0.07–0.27) | 1.14 |
| d-MA (30 min) | 0.15 (0.08–0.29) # | 1.06 |
| PAL-329 (30 min) | 16.22 (15.6–16.8) * | 0.01 |
| l-MA (10 min) | 0.79 (0.73–0.86) * | 0.20 |
| PAL-169 (30 min) | ND | ND |
ND - not determined
significantly less potent than cocaine
n=3
