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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Sep 9;234(23-24):3455–3465. doi: 10.1007/s00213-017-4731-5

Table 3.

ED80 estimates (95% C.L.) and relative potency of cocaine after pretreatment with nonselective monoamine releasers. n=4.

Drug ED80(mg/kg) Relative Potency
Cocaine 0.17 (0.11–0.27) 1
+ 0.032 mg/kg d-Amph 0.17 (0.10–0.28) 1.00
+ 0.1 mg/kg d-Amph 0.05 (0.03–0.10)* 3.40
+ 0.032 mg/kg d-MA 0.13 (0.08–0.20) 1.31
+ 0.1 mg/kg d-MA 0.08 (0.04–0.18) 2.13
+ 0.1 mg/kg l-MA 0.21 (0.11–0.41) 0.81
+ 0.32 mg/kg l-MA 0.11 (0.05–0.23) 1.54
+ 3.2 mg/kg PAL-329 0.10 (0.06–0.17) 1.70
+ 10.0 mg/kg PAL-329 0.05 (0.04–0.08)* 3.40
+ 1.0 mg/kg PAL-169 0.20 (0.11–0.38) 0.85
+ 3.2 mg/kg PAL-169# 0.12 (0.06–0.25) 1.42
#

n=3

*

significantly different from cocaine alone