Figure 5. Effects of Shifting the Balance between Ceramide and Long-chain Bases in Aneuploid Strains.
(A) Doubling times of disomes (black bars) and disomes harboring csg2Δ (open bars) relative to WT at 37°C. The average of 3 biological replicates is shown. Error bars represent +/− standard deviation (SD). * represent p-value < 0.05, paired Student’s t-test.
(B) Summary of the effects of several genes deletions and drugs that target the synthesis of sphingolipids on the fitness of thirteen disomes.
See also Figure S5.