Figure 2.

Fitting extended beta distributions to measured amplitude histograms. (A) Four‐state Markov model used for the generation of the theoretical amplitude histograms (extended beta distributions) by simulated current traces. (B,C) Representative current amplitude histograms of Kcv_NTS in 0.1 m KCl, pH 7 (gray) and the best fit with the model in (A) (black). Regions dominated by one of the closed states F, M, or S are indicated. At +160 mV (B), both the closed (at 0 pA) and open peak (at 14.6 pA) are well defined. At ‐160 mV (C), the open peak is extremely broadened and skewed, corresponding to the large, asymmetric open‐channel noise in the current trace (Fig. 1C).