Table 3.

Adverse Events (safety population)

Adverse Event	Grade 1 to 2		Grade 3 to 4
	No.	%	No.	%
Diarrhea	54	81	2	3
Fatigue	53	79	4	6
Peripheral neuropathy	53	79	2	3
Alopecia	48	72	0
AST elevation	42	63	2	3
ALT elevation	37	55	2	3
Dry skin	35	52	1	1.5
Mucositis	37	55	0
Acneiform rash	37	55	0
Nausea	33	49	1	1.5
Arthralgia	36	54	0
Hot flashes	33	49	0
Dyspepsia	26	43	0
Xerophthalmia	28	42	0
Palmar-plantar erythrodysesthesia syndrome	25	37	2	3
Anorexia	23	34	0
Cough	35	52	0
Peripheral edema	26	39	0
Epistaxis	25	37	0
Epiphora	24	36	0
Dyspnea	22	33	0

NOTE. Safety population includes all patients who received at least one dose of study drug. Adverse events of all grades shown have a frequency of 25% or higher.