Table 3.
The Joint Effects of Cigarette Smoking with DNMT3B -149 Genotypes for Lung Cancer Risk
| Variables | Smoking status | Pack-years of smoking | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Never smokers | Current and ever smokers | 0 | 1-39 | ≥40 | ||||||
| CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | |
| DNMT3B -149 genotypes | ||||||||||
| TT | 83/242 | 1.12 (0.39-3.22) | 100/103 | 7.69 (2.55-23.14)b | 83/243 | 1.12 (0.39-3.21) | 37/52 | 5.62 (1.77-17.89)b | 63/51 | 9.57 (3.09-29.66)b |
| CT | 5/20 | 1 | 2/15 | 0.89 (0.13-6.16) | 5/20 | 1 | 0/6 | 0.41 (0.18-0.93) | 2/9 | 1.43 (0.19-10.80) |
| TT | 83/242 | 1.09 (0.37-3.21) | 100/103 | 11.03 (1.55-78.50)b | 83/243 | 1.09 (0.37-3.21) | 37/52 | 3.38 (0.58-19.75) | 63/51 | 7.93 (0.92-68.43) |
| CT | 5/20 | 1 | 2/15 | 1 | 5/20 | 1 | 0/6 | 1 | 2/9 | 1 |
| Test for interaction | χ2=4.75 (1 df); P=0.03 | χ2=6.26 (2 df); P=0.04 | ||||||||
a
Data were matched by age and gender, calculated by (exact) conditional logistic regression and adjusted for green tea consumption, exposure to cooking fumes, and family history of lung cancer;
b
P<0.01.