Table 1. Cross-neutralization ability of FNAV against venoms from N. kaouthia, N. siamensis and O. hannah.
Venom | Lethality | FNAV | |||
---|---|---|---|---|---|
LD50a (μg/g) | MLDb (μg/g) | ED50 (μL/mouse) | ER50 (mg/ml) | Potencyc (mg/ml) | |
Naja kaouthia | 0.34 (0.22–0.39) | 0.471 ± 0.02 | 4.02 (1.27–5.43) | 2.19 (1.16–6.91) | 0.49 |
Naja siamensis | 0.56 (0.35–0.62) | 0.756 ± 0.05 | 18.33 (0.59–1.04) | 0.85 (0.65–1.43) | 0.23 |
Ophiophagus hannah | 0.98 (0.75–1.08) | 1.325 ± 0.08 | NEd | NE | NE |
a LD50: Median Lethal Dose—the dose of venom that induces lethality in 50% of subcutaneously injected mice (20–25 g). The values in parentheses are 95% confidence limits.
b MLD: Minimum Lethal Dose—the lowest dose of venom that induces lethality in 100% of subcutaneously injected mice.
c Potency: defined as the amount of venom in milligram was completely neutralized (100% protection) per milliliter of antivenom.
d NE: Display ineffective.