Table 1.
Effect of OJ on body weight, urine volume and serum glucose level in streptozotocin induced diabetic rats.
| Day | Group-I (Normal control) | Group-II (Diabetic control) | Group-III (Metformin-treated) | Group-IV (OJ-treated) | Group-V (OJ-Metformin treated) |
|---|---|---|---|---|---|
| Body weight (g) | |||||
| 0 | 210.00 ± 8.94 | 208.01 ± 7.92 | 208.00 ± 6.01 | 207.00 ± 6.15 | 217.00 ± 6.67 |
| 7 | 320.00 ± 15.70 | 292.00 ± 6.01 | 323.00 ± 23.50 | 277.00 ± 30.00 | 234.13 ± 13.10 |
| 14 | 332.00 ± 18.30 | 253.00 ± 8.82† | 350.00 ± 28.80∗∗ | 287.00 ± 23.60 | 193.00 ± 11.20 |
| 21 | 335.00 ± 20.50 | 227.00 ± 10.20†† | 355.00 ± 25.40∗∗∗ | 285.00 ± 26.30 | 198.00 ± 12.20 |
| Urine volume (ml/5 h) | |||||
| 0 | 1.20 ± 0.22 | 2.03 ± 0.37 | 1.48 ± 0.31 | 1.08 ± 0.18 | 1.60 ± 0.42 |
| 7 | 1.73 ± 0.32 | 8.65 ± 1.10††† | 4.73 ± 0.82∗∗ | 3.12 ± 0.55∗∗∗ | 2.67 ± 0.76∗∗∗ |
| 14 | 1.87 ± 0.32 | 9.42 ± 0.98††† | 6.12 ± 0.53∗∗ | 2.23 ± 0.42∗∗∗ | 1.93 ± 0.36∗∗∗ |
| 21 | 1.85 ± 0.32 | 10.50 ± 2.03††† | 5.47 ± 1.09∗ | 2.37 ± 0.38∗∗∗ | 1.77 ± 0.42∗∗∗ |
| Serum glucose (mg/dl) | |||||
| 0 | 86.00 ± 1.24 | 83.60 ± 2.04 | 101.00 ± 4.21 | 87.00 ± 7.21 | 83.40 ± 4.42 |
| 7 | 112.00 ± 7.91 | 361.00 ± 7.72††† | 243.00 ± 34.30∗ | 203.00 ± 29.70∗∗∗ | 356.00 ± 9.45 |
| 14 | 125.00 ± 13.20 | 354.00 ± 17.60††† | 241.00 ± 24.80∗ | 211.00 ± 22.70∗∗ | 229.00 ± 37.10∗ |
| 21 | 78.40 ± 5.14 | 348.00 ± 6.05††† | 170.00 ± 45.00∗∗∗ | 143.00 ± 13.10∗∗∗ | 237.00 ± 17.30∗ |
Values are expressed as mean ± SEM, n = 6, †p < 0.05; ††p < 0.01; †††p < 0.001 vs. normal control, ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 vs. diabetic control. Values of diabetic control group were compared with normal control and those of drug-treated groups with diabetic control.