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. Author manuscript; available in PMC: 2017 Dec 30.
Published in final edited form as: Annu Rev Chem Biomol Eng. 2017 Jun 7;8:13–39. doi: 10.1146/annurev-chembioeng-060816-101254

Figure 3.

Figure 3

Memory erasure with photoactivatable Rac1 targeted to activated synapses (AS-PaRac1). (a) Schematic of AS-PaRac1 activation in response to a light stimulus. (b) AS-PaRac1 engineered to target active dendritic spines, where blue light stimulation triggers dendritic spine shrinkage and disruption of synaptic connection (red arrows). (c) Repeated motor tasks activate similar synaptic patterns. Expression map of AS-PaRac1 within the adult brain (left) after a series of rotarod trainings and (right) after memory erasure and retraining shows a large amount of overlap in AS-PaRac1 location. Adapted with permission from Reference 97, Macmillan Publishers Ltd., Nature ©2015.