Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 27;13:161–174. doi: 10.2147/IJN.S143871

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Peng et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

QD probe-based molecular imaging methods.

Notes: QD probe-based single molecular imaging. (A1) Type IV collagen was stained yellow by QDs-585-conjugated antibody nanoprobe (yellow arrow); the area that had been degraded was revealed (red arrow). (A2) Infiltrating macrophages were stained green by QDs-525-conjugated nanoprobe (green arrow). (A3) MMP-9 was stained red by QDs-655-conjugated nanoprobe (red arrow). (A4) MMP-9 is mainly expressed in the cytoplasm of cancer cells (red arrow) but not nuclear cells (blue arrow). QD probe-based double molecular imaging. (B1 and B2) Type collagen (yellow arrows) and MMP-9 (red arrows) are labeled simultaneously in GC tissues with nanoprobes QDs-585 and QDs-655, respectively. (B3 and B4) Type collagen (green arrows) and LOX (yellow arrows) are labeled simultaneously in GC tissues with nanoprobes QDs-525 and QDs-585, respectively. (C1–C4) Infiltrating macrophages (green arrows), LOX (yellow arrows) and neovessels (red arrows) are labeled simultaneously in GC tissues with nanoprobes QDs-525, QDs-585 and QDs-655, respectively. In C3, the expression of LOX was significantly higher than that in C2. Major vessels were microvessels. Magnification: 200× (A1, B1, B3, C2 and C3), 400× (A2, A3, B2, B4 and C4), 100× (C1) and 1,000× (A4). Scale bar: 50 μm for (A1, B1, B3, C2 and C3), 20 μm for (A2, A3, B2, B4 and C4), 100 μm for (C1) and 10 μm for (A4).

Abbreviations: QD, quantum dot; MMP-9, matrix metalloproteinase 9; GC, gastric cancer; LOX, lysyl oxidase.